Prof. Shabir A. Madhi
Founder & Executive Director
About
Professor Shabir A. Madhi is the dean of the Faculty of Health Sciences at the University of the Witwatersrand and a National Research Foundation A-rated scientist. He is a professor of Vaccinology in the School of Pathology at Wits and the director of the world-renowned Medical Research Council, Vaccines and Infectious Diseases Analytics Research Unit (VIDA). His qualifications include MBBCh (Wits), MMed (Wits), FCPaeds (SA) and PhD.
Shabir is the National Research Foundation/Department of Science and Innovation SARChI Chair in Vaccine Preventable Diseases as well as the co-director of African Leadership in Vaccinology Expertise (ALIVE). He chairs the National Advisory Group on Immunization in South Africa. Madhi was formerly President of the World Society of Infectious Diseases and he is the immediate past executive director of South Africa’s National Institute of Communicable Diseases.
As a trained paediatrician, Shabir’s research has focused on the epidemiology and clinical development of vaccines against pneumonia and diarrhoeal disease. These studies have informed World Health Organization recommendations on the use of the lifesaving pneumococcal conjugate vaccine and rotavirus vaccine in children; and influenza vaccination of pregnant women. In 2016, Shabir received the European and Developing Countries Clinical Trial Partnership Award for Scientific Leadership and in 2013 the Medical Research Council Lifetime Award Platinum Medal, amongst other accolades.
Publications
, 2023. Immunogenicity of tetanus, diphtheria and acellular pertussis vaccination among pregnant women living with and without HIV. AIDS.
, 2023. Metagenomic sequencing of post-mortem tissue samples for the identification of pathogens associated with neonatal deaths. Nat Commun 14(1):5373
, 2023. State-of-the-Science of human papillomavirus vaccination in women with human immunodeficiency Virus: Summary of a scientific workshop. Prev Med Rep 35:102331
, 2023. Immune responses against group B Streptococcus monovalent and pentavalent capsular polysaccharide tetanus toxoid conjugate vaccines in Balb/c mice. iScience 26(8):107380
, 2023. Causes of Death Among Infants and Children in the Child Health and Mortality Prevention Surveillance (CHAMPS) Network. JAMA Netw Open 6(7):e2322494
, 2023. Are bivalent vaccines better than ancestral-virus monovalent vaccines in protecting against severe omicron COVID-19? Lancet Infect Dis.
, 2023. Potential for Maternally Administered Vaccine for Infant Group B Streptococcus. N Engl J Med 389(3):215-227
, 2023. Immunogenicity and seroefficacy of 10-valent and 13-valent pneumococcal conjugate vaccines: a systematic review and network meta-analysis of individual participant data. EClinicalMedicine 61:102073
, 2023. Safety of COVID-19 booster dose: is the juice worth the squeeze? Lancet Infect Dis 23(10):1097-1099
, 2023. ChAdOx1 nCoV-19 (AZD1222) vaccine-induced Fc receptor binding tracks with differential susceptibility to COVID-19. Nat Immunol 24(7):1161-1172
, 2023. Opportunities and challenges of leveraging COVID-19 vaccine innovation and technologies for developing sustainable vaccine manufacturing capabilities in Africa. Lancet Infect Dis 23(8):e288-e300
, 2023. Shifting the center of gravity for addressing the rising cancer disease burden in Africa: A rationale for African-based integrative infectious diseases and oncology research. PLOS Glob Public Health 3(5):e0001970
, 2023. The attributable fraction of respiratory syncytial virus among patients of different ages with influenza-like illness and severe acute respiratory illness in a high HIV prevalence setting, South Africa, 2012-2016. Int J Infect Dis 134:71-77
, 2023. Streptococcus pneumoniae and other bacterial nasopharyngeal colonization seven years post-introduction of 13-valent pneumococcal conjugate vaccine in South African children. Int J Infect Dis 134:45-52
, 2023. Pulmonary sequelae in 2-year-old children after hospitalisation for respiratory syncytial virus lower respiratory tract infection during infancy: an observational study. BMJ Open Respir Res 10.
, 2023. Efficacy of primary series AZD1222 (ChAdOx1 nCoV-19) vaccination against SARS-CoV-2 variants of concern: Final analysis of a randomized, placebo-controlled, phase 1b/2 study in South African adults (COV005). Vaccine 41(23):3486-3492
, 2023. All-cause and pathogen-specific lower respiratory tract infection hospital admissions in children younger than 5 years during the COVID-19 pandemic (2020-22) compared with the pre-pandemic period (2015-19) in South Africa: an observational study. Lancet Infect Dis 23(9):1031-1041
, 2023. A Qualitative Study Exploring Motivators and Barriers to COVID-19 Vaccine Uptake among Adults in South Africa and Zimbabwe. Vaccines (Basel) 11.
, 2023. In-silico identification of potential inhibitors against FabI protein in Klebsiella pneumoniae. J Biomol Struct Dyn.
, 2023. Review and Update of Active and Passive Immunization Against Respiratory Syncytial Virus. BioDrugs 37(3):295-309
, 2023. Optimization of a high-throughput nanofluidic real-time PCR to detect and quantify of 15 bacterial species and 92 Streptococcus pneumoniae serotypes. Sci Rep 13(1):4588
, 2023. Single priming and booster dose of ten-valent and 13-valent pneumococcal conjugate vaccines and Streptococcus pneumoniae colonisation in children in South Africa: a single-centre, open-label, randomised trial. Lancet Child Adolesc Health 7(5):326-335
, 2023. Longitudinal IgA and IgG Response, and ACE2 Binding Blockade, to Full-Length SARS-CoV-2 Spike Protein Variants in a Population of Black PLWH Vaccinated with ChAdOx1 nCoV-19. Viruses 15.
, 2023. Association of infant Rib and Alp1 surface protein N-terminal domain immunoglobulin G and invasive Group B Streptococcal disease in young infants. Vaccine 41(10):1679-1683
, 2023. Novavax NVX-COV2373 triggers neutralization of Omicron sub-lineages. Sci Rep 13(1):1222
, 2023. T-cell responses induced by ChAdOx1 nCoV-19 (AZD1222) vaccine to wild-type severe acute respiratory syndrome coronavirus 2 among people with and without HIV in South Africa. AIDS 37(1):105-112
, 2023. Durability of ChAdOx1 nCoV-19 (AZD1222) vaccine and hybrid humoral immunity against variants including omicron BA.1 and BA.4 6 months after vaccination (COV005): a post-hoc analysis of a randomised, phase 1b-2a trial. Lancet Infect Dis 23(3):295-306
, 2022. Coronavirus Host Genomics Study: South Africa (COVIGen-SA). Glob Health Epidemiol Genom 2022:7405349
, 2022. Insights on the differentiation of stillbirths and early neonatal deaths: A study from the Child Health and Mortality Prevention Surveillance (CHAMPS) network. PLoS One 17(7):e0271662
, 2022. COVID-19 vaccines in pregnancy. Trends Mol Med 28(8):662-680
, 2022. Immunogenicity and safety of a SARS-CoV-2 recombinant spike protein nanoparticle vaccine in people living with and without HIV-1 infection: a randomised, controlled, phase 2A/2B trial. Lancet HIV 9(5):e309-e322
, 2022. Vitamin D Deficiency and Its Association with Iron Deficiency in African Children. Nutrients 14.
, 2022. Estimation of invasive Group B Streptococcus disease risk in young infants from case-control serological studies. BMC Med Res Methodol 22(1):85
, 2022. Decoupling of omicron variant infections and severe COVID-19. Lancet 399(10329):1047-1048
, 2022. Building the concept for WHO Evidence Considerations for Vaccine Policy (ECVP): Tuberculosis vaccines intended for adults and adolescents as a test case. Vaccine 40(12):1681-1690
, 2022. The association between early-onset sepsis and neonatal encephalopathy. J Perinatol 42(3):354-358
, 2022. Correlation of dried blood spots and plasma for quantification of Immunoglobulin (IgG) against Receptor binding domain and full length spike protein of SARS-CoV-2. J Virol Methods 300:114394
, 2021. The political theatre of the UK's travel ban on South Africa. Lancet 398(10318):2211-2213
, 2021. Infant serotype specific anti-capsular immunoglobulin G antibody and risk of invasive group B Streptococcal disease. Vaccine 39(47):6813-6816
, 2021. Safety and immunogenicity of the ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 in people living with and without HIV in South Africa: an interim analysis of a randomised, double-blind, placebo-controlled, phase 1B/2A trial. Lancet HIV 8(9):e568-e580
, 2021. Mortality in children aged <5 years with severe acute respiratory illness in a high HIV-prevalence urban and rural areas of South Africa, 2009-2013. PLoS One 16(8):e0255941
, 2021. Epidemiology of severe COVID-19 from South Africa. Lancet HIV 8(9):e524-e526
, 2021. Cytokine profiles in children with acute intussusception in South Africa. Cytokine 146:155639
, 2021. Prevalence and predictors of vitamin D deficiency in young African children. BMC Med 19(1):115
, 2021. Efficacy of NVX-CoV2373 Covid-19 Vaccine against the B.1.351 Variant. N Engl J Med 384(20):1899-1909
, 2021. Efficacy of the ChAdOx1 nCoV-19 Covid-19 Vaccine against the B.1.351 Variant. N Engl J Med 384(20):1885-1898
, 2021. Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials. Lancet 397(10277):881-891
, 2021. Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK. Lancet 397(10269):99-111
, 2020. Respiratory Syncytial Virus Vaccination during Pregnancy and Effects in Infants. N Engl J Med 383(5):426-439
, 2020. Safety and immunogenicity of a parenteral trivalent P2-VP8 subunit rotavirus vaccine: a multisite, randomised, double-blind, placebo-controlled trial. Lancet Infect Dis 20(7):851-863
, 2020. Residual colonization by vaccine serotypes in rural South Africa four years following initiation of pneumococcal conjugate vaccine immunization. Expert Rev Vaccines 19(4):383-393
, 2020. Computer-aided diagnosis for World Health Organization-defined chest radiograph primary-endpoint pneumonia in children. Pediatr Radiol 50(4):482-491
, 2019. Vaccinology in sub-Saharan Africa. BMJ Glob Health 4(5):e001363
, 2019. Performance of Surveillance Case Definitions in Detecting Respiratory Syncytial Virus Infection Among Young Children Hospitalized With Severe Respiratory Illness-South Africa, 2009-2014. J Pediatric Infect Dis Soc 8(4):325-333
, 2018. Special focus on challenges and opportunities for the development and use of vaccines in Africa. Hum Vaccin Immunother 14(10):2335-2339
, 2018. Treatment and outcomes in children with multidrug-resistant tuberculosis: A systematic review and individual patient data meta-analysis. PLoS Med 15(7):e1002591
, 2017. Preliminary report from the World Health Organisation Chest Radiography in Epidemiological Studies project. Pediatr Radiol 47(11):1399-1404
, 2017. Respiratory syncytial virus in adults with severe acute respiratory illness in a high HIV prevalence setting. J Infect 75(4):346-355
, 2017. Prospects for preventing infant invasive GBS disease through maternal vaccination. Vaccine 35(35 Pt A):4457-4460
, 2016. The Cape Town Declaration on Vaccines 2012: Unlocking the full potential of vaccines in Africa. Vaccine 34(33):3713-4
, 2016. Advocating for efforts to protect African children, families, and communities from the threat of infectious diseases: report of the First International African Vaccinology Conference. Pan Afr Med J 23:53
, 2016. Epidemiology of Acute Lower Respiratory Tract Infection in HIV-Exposed Uninfected Infants. Pediatrics 137.
, 2016. Sapovirus prevalence in children less than five years of age hospitalised for diarrhoeal disease in South Africa, 2009-2013. J Clin Virol 78:82-8
, 2016. Paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome in children. Pediatr Pulmonol 51(2):157-64
, 2015. Parainfluenza Virus Infection Among Human Immunodeficiency Virus (HIV)-Infected and HIV-Uninfected Children and Adults Hospitalized for Severe Acute Respiratory Illness in South Africa, 2009-2014. Open Forum Infect Dis 2(4):ofv139
, 2015. Human metapneumovirus-associated severe acute respiratory illness hospitalisation in HIV-infected and HIV-uninfected South African children and adults. J Clin Virol 69:125-32
, 2015. Evaluation of two influenza surveillance systems in South Africa. PLoS One 10(3):e0120226
, 2015. Mortality amongst patients with influenza-associated severe acute respiratory illness, South Africa, 2009-2013. PLoS One 10(3):e0118884
, 2015. Epidemiology of severe acute respiratory illness (SARI) among adults and children aged ≥5 years in a high HIV-prevalence setting, 2009-2012. PLoS One 10(2):e0117716
, 2015. Influenza virus infection is associated with increased risk of death amongst patients hospitalized with confirmed pulmonary tuberculosis in South Africa, 2010-2011. BMC Infect Dis 15:26
, 2015. Epidemiology of viral-associated acute lower respiratory tract infection among children <5 years of age in a high HIV prevalence setting, South Africa, 2009-2012. Pediatr Infect Dis J 34(1):66-72
, 2014. Effectiveness of monovalent human rotavirus vaccine against admission to hospital for acute rotavirus diarrhoea in South African children: a case-control study. Lancet Infect Dis 14(11):1096-1104
, 2014. High nasopharyngeal pneumococcal density, increased by viral coinfection, is associated with invasive pneumococcal pneumonia. J Infect Dis 210(10):1649-57
, 2014. Radiologic diagnosis of chest infection in children: WHO end-point consolidation. Pediatr Radiol 44(6):685-6
, 2013. Impact of rotavirus vaccine on childhood diarrheal hospitalization after introduction into the South African public immunization program. Pediatr Infect Dis J 32(12):1359-64
, 2013. Temporal changes in pneumococcal colonization in a rural African community with high HIV prevalence following routine infant pneumococcal immunization. Pediatr Infect Dis J 32(11):1270-8
, 2003. Respiratory syncytial virus associated illness in high-risk children and national characterisation of the circulating virus genotype in South Africa. J Clin Virol 27(2):180-9
, 2003. High burden of invasive Streptococcus agalactiae disease in South African infants. Ann Trop Paediatr 23(1):15-23
, 2002. Ineffectiveness of trimethoprim-sulfamethoxazole prophylaxis and the importance of bacterial and viral coinfections in African children with Pneumocystis carinii pneumonia. Clin Infect Dis 35(9):1120-6
, 2002. Reduced effectiveness of Haemophilus influenzae type b conjugate vaccine in children with a high prevalence of human immunodeficiency virus type 1 infection. Pediatr Infect Dis J 21(4):315-21
Publication list retrieved from NCBI using ImpactPubs
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