Dr Renate Strehlau
Clinical Researcher
About
Dr Renate Strehlau is a clinical researcher and the deputy director of Nkanyezi, a satellite site of Wits VIDA Research Unit.
Based within the Department of Paediatrics and Child Health at the Rahima Moosa Mother and Child Hospital (RMMCH), Renate manages an active research unit focused primarily on paediatric HIV treatment, novel drug development, and mother-to child HIV transmission.
She has a special interest in paediatric neurodevelopment and has completed her Masters Degree on this topic. Renate participates in the teaching of undergraduate medical students and the supervision of research projects.
Publications
, 2023. Potential for Maternally Administered Vaccine for Infant Group B Streptococcus. N Engl J Med 389(3):215-227
, 2023. Microbiota in the oral cavity of school-age children with HIV who started antiretroviral therapy at young ages in South Africa. AIDS 37(10):1583-1591
, 2023. Nirsevimab for Prevention of RSV in Term and Late-Preterm Infants. N Engl J Med 388(16):1533-1534
, 2023. Adverse maternal, fetal, and newborn outcomes among pregnant women with SARS-CoV-2 infection: an individual participant data meta-analysis. BMJ Glob Health 8.
, 2023. Disclosure to South African children about their own HIV status over time. AIDS Care 35(3):334-340
, 2022. Antepartum SARS-CoV-2 infection and adverse birth outcomes in South African women. J Glob Health 12:05050
, 2022. Active Intrapartum SARS-CoV-2 Infection and Pregnancy Outcomes. Am J Perinatol 39(S 01):S42-S48
, 2022. Comparison of quantitative ultrasonography and dual X-ray absorptiometry for bone status assessment in South African children living with HIV. PLoS One 17(10):e0276290
, 2022. FCGR3A gene duplication, FcγRIIb-232TT and FcγRIIIb-HNA1a associate with an increased risk of vertical acquisition of HIV-1. PLoS One 17(9):e0273933
, 2022. Healthy dynamics of CD4 T cells may drive HIV resurgence in perinatally-infected infants on antiretroviral therapy. PLoS Pathog 18(8):e1010751
, 2022. Maternal-foetal transfer of severe acute respiratory syndrome coronavirus 2 antibodies among women with and those without HIV infection. AIDS 36(13):1777-1782
, 2022. Evaluation of submaximal endurance in young children living with HIV. S Afr J Physiother 78(1):1613
, 2022. Safety of Nirsevimab for RSV in Infants with Heart or Lung Disease or Prematurity. N Engl J Med 386(9):892-894
, 2022. Nirsevimab for Prevention of RSV in Healthy Late-Preterm and Term Infants. N Engl J Med 386(9):837-846
, 2022. Predictors of Cell-Associated Human Immunodeficiency Virus (HIV)-1 DNA Over 1 Year in Very Early Treated Infants. Clin Infect Dis 74(6):1047-1054
, 2021. Evaluating the performance of the GeneXpert HIV-1 qualitative assay as a consecutive test for a new early infant diagnosis algorithm in South Africa. S Afr Med J 111(9):857-861
, 2021. An HIV Vaccine Protective Allele in FCGR2C Associates With Increased Odds of Perinatal HIV Acquisition. Front Immunol 12:760571
, 2021. Risk factors for COVID-19-related in-hospital mortality in a high HIV and tuberculosis prevalence setting in South Africa: a cohort study. Lancet HIV 8(9):e554-e567
, 2021. Difference in mortality among individuals admitted to hospital with COVID-19 during the first and second waves in South Africa: a cohort study. Lancet Glob Health 9(9):e1216-e1225
, 2021. Persistently lower bone mass and bone turnover among South African children living with well controlled HIV. AIDS 35(13):2137-2147
, 2021. Virologic Response to Very Early HIV Treatment in Neonates. J Clin Med 10.
, 2021. Normalization of B Cell Subsets but Not T Follicular Helper Phenotypes in Infants With Very Early Antiretroviral Treatment. Front Pediatr 9:618191
, 2021. Outcomes of newborn hearing screening at an academic secondary level hospital in Johannesburg, South Africa. S Afr J Commun Disord 68(1):e1-e8
, 2021. Neurodevelopment in early treated HIV-infected infants participating in a developmental stimulation programme compared with controls. Child Care Health Dev 47(2):154-162
, 2021. Low Pretreatment Viral Loads in Infants With HIV in an Era of High-maternal Antiretroviral Therapy Coverage. Pediatr Infect Dis J 40(1):55-59
, 2021. Switch to Efavirenz Attenuates Lipoatrophy in Girls With Perinatal HIV. J Pediatr Gastroenterol Nutr 72(1):e15-e20
, 2020. Behavioral Functioning and Quality of Life in South African Children Living with HIV on Antiretroviral Therapy. J Pediatr 227:308-313.e2
, 2020. Bone turnover markers in children living with HIV remaining on ritonavir-boosted lopinavir or switching to efavirenz. Bone 138:115500
, 2020. Quantifying the Dynamics of HIV Decline in Perinatally Infected Neonates on Antiretroviral Therapy. J Acquir Immune Defic Syndr 85(2):209-218
, 2020. Response to Zhao and Zhou: Diagnosis of HIV infection in breastfed infants of mothers on antiretroviral therapy. AIDS 34(5):798-799
, 2020. Deficits in Bone Architecture and Strength in Children Living With HIV on Antiretroviral Therapy. J Acquir Immune Defic Syndr 84(1):101-106
, 2020. A description of early neurodevelopment in a cohort of HIV-exposed uninfected children. AIDS Care 32(11):1421-1428
, 2020. Abacavir Exposure in Children Cotreated for Tuberculosis with Rifampin and Superboosted Lopinavir-Ritonavir. Antimicrob Agents Chemother 64.
, 2020. Early antiretroviral treatment of infants to attain HIV remission. EClinicalMedicine 18:100241
, 2020. Negative Diagnostic PCR Tests in School-Aged, HIV-Infected Children on Antiretroviral Therapy Since Early Life in Johannesburg, South Africa. J Acquir Immune Defic Syndr 83(4):381-389
, 2020. Educational delays among children living with perinatally-acquired HIV in Johannesburg, South Africa. AIDS Care 32(4):438-444
, 2020. Mitochondrial Impairment in Well-Suppressed Children with Perinatal HIV-Infection on Antiretroviral Therapy. AIDS Res Hum Retroviruses 36(1):27-38
, 2019. Bone Quality Measured Using Calcaneal Quantitative Ultrasonography Is Reduced Among Children with HIV in Johannesburg, South Africa. J Pediatr 215:267-271.e2
, 2019. Cost-Effectiveness of Preemptive Switching to Efavirenz-Based Antiretroviral Therapy for Children With Human Immunodeficiency Virus. Open Forum Infect Dis 6(7):ofz276
, 2019. Distinct epigenetic profiles in children with perinatally-acquired HIV on antiretroviral therapy. Sci Rep 9(1):10495
, 2019. HIV diagnostic challenges in breast-fed infants of mothers on antiretroviral therapy. AIDS 33(11):1751-1756
, 2019. Early infant diagnosis HIV-1 PCR cycle-threshold predicts infant viral load at birth. J Clin Virol 114:21-25
, 2018. 12-month outcomes of HIV-infected infants identified at birth at one maternity site in Johannesburg, South Africa: an observational cohort study. Lancet HIV 5(12):e706-e714
, 2018. Biomarkers of Aging in HIV-Infected Children on Suppressive Antiretroviral Therapy. J Acquir Immune Defic Syndr 78(5):549-556
, 2018. Age at antiretroviral therapy initiation and cell-associated HIV-1 DNA levels in HIV-1-infected children. PLoS One 13(4):e0195514
, 2018. Neurodevelopmental assessment of HIV-exposed uninfected and early-treated HIV-infected children: study protocol. BMC Res Notes 11(1):235
, 2018. Decreased bone turnover in HIV-infected children on antiretroviral therapy. Arch Osteoporos 13(1):40
, 2018. Substituting Abacavir for Stavudine in Children Who Are Virally Suppressed Without Lipodystrophy: Randomized Clinical Trial in Johannesburg, South Africa. J Pediatric Infect Dis Soc 7(3):e70-e77
, 2018. Reply to Van de Wijer et al. Clin Infect Dis 66(7):1151-1152
, 2018. Patterns of Growth, Body Composition, and Lipid Profiles in a South African Cohort of Human Immunodeficiency Virus-Infected and Uninfected Children: A Cross-Sectional Study. J Pediatric Infect Dis Soc 7(2):143-150
, 2017. Prevalence and outcomes of HIV-1 diagnostic challenges during universal birth testing - an urban South African observational cohort. J Int AIDS Soc 20(Suppl 6):21761
, 2017. Switching to Efavirenz Versus Remaining on Ritonavir-boosted Lopinavir in Human Immunodeficiency Virus-infected Children Exposed to Nevirapine: Long-term Outcomes of a Randomized Trial. Clin Infect Dis 65(3):477-485
, 2017. Dietary Inadequacies in HIV-infected and Uninfected School-aged Children in Johannesburg, South Africa. J Pediatr Gastroenterol Nutr 65(3):332-337
, 2017. Early age at start of antiretroviral therapy associated with better virologic control after initial suppression in HIV-infected infants. AIDS 31(3):355-364
, 2017. Extent of disclosure: what perinatally HIV-infected children have been told about their own HIV status. AIDS Care 29(3):378-386
, 2017. Unusually High Calcaneal Speed of Sound Measurements in Children with Small Foot Size. Ultrasound Med Biol 43(1):357-361
, 2016. Benefits and Risks of Antiretroviral Therapy for Perinatal HIV Prevention. N Engl J Med 375(18):1726-1737
, 2016. HIV-associated neurodevelopmental delay: prevalence, predictors and persistence in relation to antiretroviral therapy initiation and viral suppression. Child Care Health Dev 42(6):881-889
, 2016. Efavirenz is associated with higher bone mass in South African children with HIV. AIDS 30(16):2459-2467
, 2016. Effect of Lopinavir and Nevirapine Concentrations on Viral Outcomes in Protease Inhibitor-experienced HIV-infected Children. Pediatr Infect Dis J 35(12):e378-e383
, 2016. Decreased Vigorous Physical Activity in School-Aged Children with Human Immunodeficiency Virus in Johannesburg, South Africa. J Pediatr 172:103-9
, 2016. Developmental status of preschool children receiving cART: a descriptive cohort study. Child Care Health Dev 42(3):410-4
, 2016. Case report: Severe central nervous system manifestations associated with aberrant efavirenz metabolism in children: the role of CYP2B6 genetic variation. BMC Infect Dis 16:56
, 2015. Efavirenz-Based Antiretroviral Therapy Among Nevirapine-Exposed HIV-Infected Children in South Africa: A Randomized Clinical Trial. JAMA 314(17):1808-17
, 2015. PRINCE-1: safety and efficacy of atazanavir powder and ritonavir liquid in HIV-1-infected antiretroviral-naïve and -experienced infants and children aged ≥3 months to <6 years. J Int AIDS Soc 18(1):19467
, 2015. Genetic Changes in HIV-1 Gag-Protease Associated with Protease Inhibitor-Based Therapy Failure in Pediatric Patients. AIDS Res Hum Retroviruses 31(8):776-82
, 2015. Young age at start of antiretroviral therapy and negative HIV antibody results in HIV-infected children when suppressed. AIDS 29(9):1053-60
, 2014. Concordance between allele-specific PCR and ultra-deep pyrosequencing for the detection of HIV-1 non-nucleoside reverse transcriptase inhibitor resistance mutations. J Virol Methods 207:182-7
, 2014. Timing of maternal HIV testing and uptake of prevention of mother-to-child transmission interventions among women and their infected infants in Johannesburg, South Africa. J Acquir Immune Defic Syndr 65(5):e170-8
, 2014. Sex differences in responses to antiretroviral treatment in South African HIV-infected children on ritonavir-boosted lopinavir- and nevirapine-based treatment. BMC Pediatr 14:39
, 2014. Plasma lopinavir concentrations predict virological failure in a cohort of South African children initiating a protease-inhibitor-based regimen. Antivir Ther 19(4):399-406
, 2013. Poor early virologic performance and durability of abacavir-based first-line regimens for HIV-infected children. Pediatr Infect Dis J 32(8):851-5
, 2013. Initiation of antiretroviral therapy before 6 months of age is associated with faster growth recovery in South African children perinatally infected with human immunodeficiency virus. J Pediatr 162(6):1138-45, 1145.e1-2
, 2013. Adherence and viral suppression among infants and young children initiating protease inhibitor-based antiretroviral therapy. Pediatr Infect Dis J 32(5):489-94
, 2013. Metabolic abnormalities and body composition of HIV-infected children on Lopinavir or Nevirapine-based antiretroviral therapy. Arch Dis Child 98(4):258-64
, 2012. Switching children previously exposed to nevirapine to nevirapine-based treatment after initial suppression with a protease-inhibitor-based regimen: long-term follow-up of a randomised, open-label trial. Lancet Infect Dis 12(7):521-30
, 2012. Lipid profiles in young HIV-infected children initiating and changing antiretroviral therapy. J Acquir Immune Defic Syndr 60(4):369-76
, 2011. Absence seizures associated with efavirenz initiation. Pediatr Infect Dis J 30(11):1001-3
, 2011. Rapid development of antiretroviral drug resistance mutations in HIV-infected children less than two years of age initiating protease inhibitor-based therapy in South Africa. AIDS Res Hum Retroviruses 27(9):945-56
, 2011. Induction therapy with protease-inhibitors modifies the effect of nevirapine resistance on virologic response to nevirapine-based HAART in children. Clin Infect Dis 52(4):514-21
, 2010. Initial response to protease-inhibitor-based antiretroviral therapy among children less than 2 years of age in South Africa: effect of cotreatment for tuberculosis. J Infect Dis 201(8):1121-31
, 2009. Immune reconstitution inflammatory syndrome among HIV-infected South African infants initiating antiretroviral therapy. AIDS 23(9):1097-107
, 1977. Measurements of extracellular and of interstitial cation activity (pK, pNa, pCa) with ion-selective electrodes. Bibl Anat.
, 1975. Proceedings: Hydrogen clearance measurements on the liver surface in situ with the multiwire electrode. Arzneimittelforschung 25(10):1670-1
, 1975. Proceedings: Microcirculatory changes during normovolemic hemodilution. Arzneimittelforschung 25(10):1670
Publication list retrieved from NCBI using ImpactPubs
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