Dr Clare Cutland
Scientific Co-Ordinator, ALIVE
About
Clare Cutland is the Scientific Coordinator of the African Leadership in Vaccinology Expertise (Alive) consortium. ALIVE was selected as the flagship entity for the University of the Witwatersrand in 2016, and aims to create African expertise and leadership in vaccinology training, research and advocacy. She has established and coordinates the MSc(Med) in the field of vaccinology at Wits, and the 10-day African advanced vaccinology short course.
Prior to her appointment in ALIVE (Nov 2018), she was a research medical officer and subsequently the deputy director of the Respiratory and Meningeal Pathogens Research Unit (RMPRU, now Wits-VIDA), based at Chris Hani Baragwanath Academic Hospital (CHBAH), Soweto, South Africa (2000-2018).
She was an investigator on numerous phase I, II and III paediatric and maternal vaccine trials and principal investigator on a phase II paediatric measles vaccine trial, a phase III quadrivalent influenza vaccine trial in children and a phase III maternal influenza immunization trial in HIV-positive women.
Clare Cutland was the clinical lead for several large grant-funded neonatal sepsis prevention (PoPS, sepsis surveillance) and maternal immunization studies (influenza, Streptococcus agalactiae / Group B streptococcus sero-correlate of protection) and an investigator on numerous maternal immunization trials (GBS, RSV), and has published on challenges and lessons learnt in maternal immunization trials. She is national coordinator for the Oxford-AZ COVID-19 vaccine trial in South Africa (April 2020 – current), and is a sub-investigator on Oxford-Astra Zeneca- and Novavax COVID-19 vaccine trials
She was involved in the GAIA Brighton collaboration definition working groups (2014-2016), and was elected as a member of the scientific board of the Brighton collaboration in 2018 (to present). She is a member of the Wits Institutional biosafety committee and working group for maternal COVID-19 vaccines.
Clare is author or co-author on over 117 peer-reviewed journal articles.
Publications
, 2023. Editorial: Vaccinations and women's reproductive health. Int J Gynaecol Obstet 162(1):1-3
, 2023. ChAdOx1 nCoV-19 (AZD1222) vaccine-induced Fc receptor binding tracks with differential susceptibility to COVID-19. Nat Immunol 24(7):1161-1172
, 2023. Standardizing case definitions for monitoring the safety of maternal vaccines globally: GAIA definitions, a review of progress to date. Int J Gynaecol Obstet 162(1):29-38
, 2023. Efficacy of primary series AZD1222 (ChAdOx1 nCoV-19) vaccination against SARS-CoV-2 variants of concern: Final analysis of a randomized, placebo-controlled, phase 1b/2 study in South African adults (COV005). Vaccine 41(23):3486-3492
, 2023. Single priming and booster dose of ten-valent and 13-valent pneumococcal conjugate vaccines and Streptococcus pneumoniae colonisation in children in South Africa: a single-centre, open-label, randomised trial. Lancet Child Adolesc Health 7(5):326-335
, 2023. A phase 3, randomized, controlled, open-label study to evaluate the persistence up to 5 years of 1 or 2 doses of meningococcal conjugate vaccine MenACWY-TT given with or without 13-valent pneumococcal conjugate vaccine in 12-14-month-old children. Vaccine 41(5):1153-1160
, 2023. T-cell responses induced by ChAdOx1 nCoV-19 (AZD1222) vaccine to wild-type severe acute respiratory syndrome coronavirus 2 among people with and without HIV in South Africa. AIDS 37(1):105-112
, 2023. Durability of ChAdOx1 nCoV-19 (AZD1222) vaccine and hybrid humoral immunity against variants including omicron BA.1 and BA.4 6 months after vaccination (COV005): a post-hoc analysis of a randomised, phase 1b-2a trial. Lancet Infect Dis 23(3):295-306
, 2023. Respiratory syncytial virus prevention within reach: the vaccine and monoclonal antibody landscape. Lancet Infect Dis 23(1):e2-e21
, 2022. Effectiveness of Influenza Vaccination of Pregnant Women for Prevention of Maternal and Early Infant Influenza-Associated Hospitalizations in South Africa: A Prospective Test-Negative Study. Open Forum Infect Dis 9(11):ofac552
, 2022. Preparing for Disease X: Ensuring Vaccine Equity for Pregnant Women in Future Pandemics. Front Med (Lausanne) 9:893292
, 2022. Advancing the Science of Vaccine Safety During the Coronavirus Disease 2019 (COVID-19) Pandemic and Beyond: Launching an International Network of Special Immunization Services. Clin Infect Dis 75(Suppl 1):S11-S17
, 2022. Operational lessons learned in conducting an international study on pharmacovigilance in pregnancy in resource-constrained settings: The WHO Global Vaccine safety Multi-Country collaboration project. Vaccine X 11:100160
, 2022. Vitamin D Deficiency and Its Association with Iron Deficiency in African Children. Nutrients 14.
, 2022. Fetal Transfer of Human Metapneumovirus-Neutralizing Antibodies Is Reduced From Mothers Living With HIV-1. J Pediatric Infect Dis Soc 11(7):341-344
, 2021. Safety and immunogenicity of the ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 in people living with and without HIV in South Africa: an interim analysis of a randomised, double-blind, placebo-controlled, phase 1B/2A trial. Lancet HIV 8(9):e568-e580
, 2021. Prevalence and predictors of vitamin D deficiency in young African children. BMC Med 19(1):115
, 2021. Severe Acute Respiratory Syndrome Coronavirus 2 Infection Among Healthcare Workers in South Africa: A Longitudinal Cohort Study. Clin Infect Dis 73(10):1896-1900
, 2021. Efficacy of the ChAdOx1 nCoV-19 Covid-19 Vaccine against the B.1.351 Variant. N Engl J Med 384(20):1885-1898
, 2021. Malaria is a cause of iron deficiency in African children. Nat Med 27(4):653-658
, 2021. Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials. Lancet 397(10277):881-891
, 2021. The Fifth International Neonatal and Maternal Immunization Symposium (INMIS 2019): Securing Protection for the Next Generation. mSphere 6.
, 2021. Pneumococcal Conjugate Vaccine Protection against Coronavirus-Associated Pneumonia Hospitalization in Children Living with and without HIV. mBio 12.
, 2021. Association of Group B Streptococcus (GBS) Serum Serotype-Specific Anticapsular Immunoglobulin G Concentration and Risk Reduction for Invasive GBS Disease in South African Infants: An Observational Birth-Cohort, Matched Case-Control Study. Clin Infect Dis 73(5):e1170-e1180
, 2021. Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK. Lancet 397(10269):99-111
, 2020. Bacterial nasopharyngeal carriage following infant immunization with pneumococcal conjugate vaccines according to a 2+1 schedule in children in South Africa: an exploratory analysis of two clinical trials. Expert Rev Vaccines 19(12):1177-1189
, 2020. Immunogenicity of influenza vaccines administered to pregnant women in randomized clinical trials in Mali and South Africa. Vaccine 38(41):6478-6483
, 2020. Immunogenicity of a single-dose compared with a two-dose primary series followed by a booster dose of ten-valent or 13-valent pneumococcal conjugate vaccine in South African children: an open-label, randomised, non-inferiority trial. Lancet Infect Dis 20(12):1426-1436
, 2020. Respiratory Syncytial Virus Vaccination during Pregnancy and Effects in Infants. N Engl J Med 383(5):426-439
, 2020. Efficacy, duration of protection, birth outcomes, and infant growth associated with influenza vaccination in pregnancy: a pooled analysis of three randomised controlled trials. Lancet Respir Med 8(6):597-608
, 2020. Obstetrics risk Assessment: Evaluation of selection criteria for vaccine research studies in pregnant women. Vaccine 38(29):4542-4547
, 2020. Influenza or Meningococcal Immunization During Pregnancy and Mortality in Women and Infants: A Pooled Analysis of Randomized Controlled Trials. Pediatr Infect Dis J 39(7):641-644
, 2020. Impact of HIV status and vaccination schedule on bacterial nasopharyngeal carriage following infant immunisation with the pneumococcal non-typeable Haemophilus influenzae protein D conjugate vaccine in South Africa. Vaccine 38(10):2350-2360
, 2020. Immunogenicity and safety of different dosing schedules of trivalent inactivated influenza vaccine in pregnant women with HIV: a randomised controlled trial. Lancet HIV 7(2):e91-e103
, 2020. Rubella seroprevalence in pregnant women living with and without HIV in Soweto, South Africa. Int J Infect Dis 91:255-260
, 2020. Measles seroprevalence in pregnant women in Soweto, South Africa: a nested cohort study. Clin Microbiol Infect 26(4):515.e1-515.e4
, 2019. The ferroportin Q248H mutation protects from anemia, but not malaria or bacteremia. Sci Adv 5(9):eaaw0109
, 2019. Trivalent influenza vaccination randomized control trial of pregnant women and adverse fetal outcomes. Vaccine 37(36):5397-5403
, 2019. Immunogenicity and Safety of an Early Measles Vaccination Schedule at 6 and 12 Months of Age in Human Immunodeficiency Virus (HIV)-Unexposed and HIV-Exposed, Uninfected South African Children. J Infect Dis 220(9):1529-1538
, 2019. Immunization in pregnancy safety surveillance in low and middle-income countries- field performance and validation of novel case definitions. Vaccine 37(22):2967-2974
, 2019. Causes of stillbirths among women from South Africa: a prospective, observational study. Lancet Glob Health 7(4):e503-e512
, 2019. Impaired Transplacental Transfer of Respiratory Syncytial Virus-neutralizing Antibodies in Human Immunodeficiency Virus-infected Versus -uninfected Pregnant Women. Clin Infect Dis 69(1):151-154
, 2018. Neutralization and hemagglutination-inhibition antibodies following influenza vaccination of HIV-infected and HIV-uninfected pregnant women. PLoS One 13(12):e0210124
, 2018. Influenza Vaccination during Pregnancy and Protection against Pertussis. N Engl J Med 378(13):1257-1258
, 2018. Immunogenicity and safety of one or two doses of the quadrivalent meningococcal vaccine MenACWY-TT given alone or with the 13-valent pneumococcal conjugate vaccine in toddlers: A phase III, open-label, randomised study. Vaccine 36(14):1908-1916
, 2018. Burden of Respiratory Syncytial Virus Infection in South African Human Immunodeficiency Virus (HIV)-Infected and HIV-Uninfected Pregnant and Postpartum Women: A Longitudinal Cohort Study. Clin Infect Dis 66(11):1658-1665
, 2017. Association between antibodies against group B Streptococcus surface proteins and recto-vaginal colonisation during pregnancy. Sci Rep 7(1):16454
, 2017. Low birth weight: Case definition & guidelines for data collection, analysis, and presentation of maternal immunization safety data. Vaccine 35(48 Pt A):6492-6500
, 2017. Congenital microcephaly: Case definition & guidelines for data collection, analysis, and presentation of safety data after maternal immunisation. Vaccine 35(48 Pt A):6472-6482
, 2017. Antibody Kinetics and Response to Routine Vaccinations in Infants Born to Women Who Received an Investigational Trivalent Group B Streptococcus Polysaccharide CRM197-Conjugate Vaccine During Pregnancy. Clin Infect Dis 65(11):1897-1904
, 2017. Maternal HIV infection associated with reduced transplacental transfer of measles antibodies and increased susceptibility to disease. J Clin Virol 94:50-56
, 2017. Efficacy of Maternal Influenza Vaccination Against All-Cause Lower Respiratory Tract Infection Hospitalizations in Young Infants: Results From a Randomized Controlled Trial. Clin Infect Dis 65(7):1066-1071
, 2017. Contribution of Serologic Assays in the Evaluation of Influenza Virus Infection Rates and Vaccine Efficacy in Pregnant Women: Report From Randomized Controlled Trials. Clin Infect Dis 64(12):1773-1779
, 2016. Temporal Changes in Invasive Group B Streptococcus Serotypes: Implications for Vaccine Development. PLoS One 11(12):e0169101
, 2016. Bordetella pertussis Infection in South African HIV-Infected and HIV-Uninfected Mother-Infant Dyads: A Longitudinal Cohort Study. Clin Infect Dis 63(suppl 4):S174-S180
, 2016. Guidance for the collection of case report form variables to assess safety in clinical trials of vaccines in pregnancy. Vaccine 34(49):6007-6014
, 2016. Neonatal death: Case definition & guidelines for data collection, analysis, and presentation of immunization safety data. Vaccine 34(49):6027-6037
, 2016. Duration of Infant Protection Against Influenza Illness Conferred by Maternal Immunization: Secondary Analysis of a Randomized Clinical Trial. JAMA Pediatr 170(9):840-7
, 2016. Influenza vaccination of pregnant women protects them over two consecutive influenza seasons in a randomized controlled trial. Expert Rev Vaccines 15(8):1055-62
, 2016. Safety and immunogenicity of an investigational maternal trivalent group B streptococcus vaccine in healthy women and their infants: a randomised phase 1b/2 trial. Lancet Infect Dis 16(8):923-34
, 2016. Invasive Group B Streptococcal Disease in South Africa: Importance of Surveillance Methodology. PLoS One 11(4):e0152524
, 2016. Serotype-Specific Cell-Mediated Immunity Associated With Clearance of Homotypic Group B Streptococcus Rectovaginal Colonization in Pregnant Women. J Infect Dis 213(12):1923-6
, 2015. Correlates of protection of serotype-specific capsular antibody and invasive Group B Streptococcus disease in South African infants. Vaccine 33(48):6793-9
, 2015. Lessons learnt from enrolment and follow up of pregnant women and their infants in clinical trials in South Africa, a low-middle income country. Vaccine 33(47):6406-12
, 2015. Association between maternal Group B Streptococcus surface-protein antibody concentrations and invasive disease in their infants. Expert Rev Vaccines 14(12):1651-60
, 2015. Maternal group B Streptococcus-related stillbirth: a systematic review. BJOG 122(11):1437-45
, 2015. Three randomized trials of maternal influenza immunization in Mali, Nepal, and South Africa: Methods and expectations. Vaccine 33(32):3801-12
, 2015. Kinetics of Hemagglutination-Inhibiting Antibodies Following Maternal Influenza Vaccination Among Mothers With and Those Without HIV Infection and Their Infants. J Infect Dis 212(12):1976-87
, 2015. Bacterial and Respiratory Viral Interactions in the Etiology of Acute Otitis Media in HIV-infected and HIV-uninfected South African Children. Pediatr Infect Dis J 34(7):753-60
, 2015. Burden of invasive group B Streptococcus disease and early neurological sequelae in South African infants. PLoS One 10(4):e0123014
, 2015. Increased risk for group B Streptococcus sepsis in young infants exposed to HIV, Soweto, South Africa, 2004-2008(1). Emerg Infect Dis 21(4):638-45
, 2015. Natural acquired humoral immunity against serotype-specific group B Streptococcus rectovaginal colonization acquisition in pregnant women. Clin Microbiol Infect 21(6):568.e13-21
, 2015. HIV-1 Is Associated With Lower Group B Streptococcus Capsular and Surface-Protein IgG Antibody Levels and Reduced Transplacental Antibody Transfer in Pregnant Women. J Infect Dis 212(3):453-62
, 2014. Influenza vaccination of pregnant women and protection of their infants. N Engl J Med 371(24):2340
, 2014. Polyomaviruses-associated respiratory infections in HIV-infected and HIV-uninfected children. J Clin Virol 61(4):571-8
, 2014. Influenza vaccination of pregnant women and protection of their infants. N Engl J Med 371(10):918-31
, 2014. Serotype-specific acquisition and loss of group B streptococcus recto-vaginal colonization in late pregnancy. PLoS One 9(6):e98778
, 2014. Cost-effectiveness of a potential group B streptococcal vaccine program for pregnant women in South Africa. Vaccine 32(17):1954-63
, 2013. Evaluation of Trans-Vag broth, colistin-nalidixic agar, and CHROMagar StrepB for detection of group B Streptococcus in vaginal and rectal swabs from pregnant women in South Africa. J Clin Microbiol 51(8):2515-9
, 2013. Acquisition of Streptococcus pneumoniae in pneumococcal conjugate vaccine-naïve South African children and their mothers. Pediatr Infect Dis J 32(5):e192-205
, 2013. Distribution of pilus islands of group B streptococcus associated with maternal colonization and invasive disease in South Africa. J Med Microbiol 62(Pt 2):249-253
, 2013. Efficacy and immunogenicity of influenza vaccine in HIV-infected children: a randomized, double-blind, placebo controlled trial. AIDS 27(3):369-79
, 2012. Maternal HIV infection and vertical transmission of pathogenic bacteria. Pediatrics 130(3):e581-90
, 2012. Risk factors for neonatal sepsis and perinatal death among infants enrolled in the prevention of perinatal sepsis trial, Soweto, South Africa. Pediatr Infect Dis J 31(8):821-6
, 2011. Serotype distribution and invasive potential of group B streptococcus isolates causing disease in infants and colonizing maternal-newborn dyads. PLoS One 6(3):e17861
, 2011. Trivalent inactivated influenza vaccine in African adults infected with human immunodeficient virus: double blind, randomized clinical trial of efficacy, immunogenicity, and safety. Clin Infect Dis 52(1):128-37
, 2009. Chlorhexidine maternal-vaginal and neonate body wipes in sepsis and vertical transmission of pathogenic bacteria in South Africa: a randomised, controlled trial. Lancet 374(9705):1909-16
Publication list retrieved from NCBI using ImpactPubs
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