Project Description

South African children: A case cohort study of neurodevelopmental impairment in survivors of invasive Group B Streptococcus disease aged 5- to 8-years.

Harden LM, Leahy S, Lala SG, Paul P, Chandna J, Lowick S, Mbatha S, Jaye T, Laughton B, Ghoor A, Sithole P, Msayi J, Kumalo N, Msibi TN, Madhi SA, Lawn JE, Dangor Z.

Clin Infect Dis. 2021 Nov 2:ciab814. doi: 10.1093/cid/ciab814. Epub ahead of print.


Invasive group B Streptococcus (iGBS) sepsis and meningitis are important causes of child mortality, but studies on neurodevelopmental impairment (NDI) after iGBS are limited. Using Griffiths Mental Development Scales–Extended Revised (GMDS-ER), we described NDI in iGBS survivors and non-iGBS children from South Africa, as part of a 5-country study.

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