Project Description

Mitochondrial Impairment in Well-Suppressed Children with Perinatal HIV-Infection on Antiretroviral Therapy.

Background: Mitochondrial impairment is reported in HIV-infected children receiving antiretroviral therapy (ART), as well as those naive to ART. Whether mitochondrial function recovers with early initiation of ART and sustained viral suppression on long-term ART is unclear. In this study, we evaluate mitochondrial markers in well-suppressed perinatally HIV-infected children initiated on ART early in life.

Author List: Shen J, Liberty A, Shiau S, Strehlau R, Pierson S, Patel F, Wang L, Burke M, Violari A, Coovadia A, Abrams EJ, Arpadi S, Foca M, Kuhn L.

Journal Name: AIDS Res Hum Retroviruses. 2020 Jan;36(1):27-38. doi: 10.1089/AID.2018.0182. Epub 2019 Jul 15. PMID: 31179720; PMCID: PMC6944140.

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