HLA antibody repertoire in infants suggests selectivity in transplacental crossing.
Background: Late in pregnancy, women produce and transfer high amounts of antibodies to the foetus. During gestation, women produce antibodies against human leukocyte antigens (HLA), including antibodies directed at foetal HLA. There is paucity of data on transplacental crossing, specificity and role of HLA antibodies in pregnancy and new‐borns.
Author List: Savulescu DM, Groome M, Malfeld SCK, Madhi S, Koen A, Jones S, Duxbury V, Scheuermaier K, De Assis Rosa D, Suchard M.
Journal Name: Am J Reprod Immunol. 2020 Aug;84(2):e13264. doi: 10.1111/aji.13264. Epub 2020 Jun 16. PMID: 32395838; PMCID: PMC7507134.